Amitriptyline — Nutrient Associations & Health Patterns
Also known as: Amitriptyline (Elavil, Endep)
Drug Class: Tricyclic antidepressant (TCA)
Tricyclic antidepressant used for depression, chronic pain, migraine prevention, fibromyalgia, IBS, insomnia, and neuropathic pain. At low doses (10–50mg), primarily used for pain and sleep. At therapeutic antidepressant doses (75–150mg), treats major depression. One of the most prescribed medications for chronic pain conditions despite being an older drug class. Only evidence-qualified catalog relationships are listed here. Other catalog entries remain unverified in this reference; absence from the list does not rule out other medication effects or interactions.
Medication and Nutrition Context
Only evidence-qualified catalog relationships are listed here. Other catalog entries remain unverified in this reference; absence from the list does not rule out other medication effects or interactions.
Common Side Effects of Amitriptyline
- Drowsiness (used therapeutically at low doses for sleep)
- Dry mouth
- Constipation
- Urinary retention
- Blurred vision
- Weight gain
- Orthostatic hypotension (dizziness on standing — fall risk)
- Heart rhythm changes (QT prolongation — cardiac risk at high doses)
Key Drug Interactions — Amitriptyline
Amitriptyline has 9 documented drug-drug interactions in WePattern's Pattern Health Intelligence database. Key interactions include:
- MAOIs (potentially fatal — 14-day washout required)
- Other serotonergic drugs (serotonin syndrome)
- CNS depressants and alcohol (additive sedation)
- Anticholinergic drugs (additive dry mouth, constipation, urinary retention, confusion)
- Blood pressure medications (additive hypotension)
- Antihistamines (additive sedation and anticholinergic effects)
Frequently Asked Questions
What nutrient associations are reported for Amitriptyline?
Only evidence-qualified catalog relationships are listed here. Other catalog entries remain unverified in this reference; absence from the list does not rule out other medication effects or interactions.
Which nutrient relationships are mapped for Amitriptyline?
Only evidence-qualified catalog relationships are listed here. Other catalog entries remain unverified in this reference; absence from the list does not rule out other medication effects or interactions.
What are the side effects of Amitriptyline?
Common side effects associated with Amitriptyline include: Drowsiness (used therapeutically at low doses for sleep); Dry mouth; Constipation; Urinary retention; Blurred vision.