Amoxicillin — Nutrient Depletion & Health Patterns
Also known as: Amoxicillin (Amoxil, Trimox, Moxatag)
Drug Class: Penicillin antibiotic
The most prescribed antibiotic in the world. A broad-spectrum penicillin-class beta-lactam used for ear, sinus, throat, lung, urinary tract, skin, and dental infections. Also used as part of H. pylori eradication therapy (with clarithromycin and omeprazole). Available in capsules, oral suspension, and chewable tablets. Generally taken in short courses (5–10 days), though gut microbiome impact can persist months.
Nutrients That Amoxicillin May Deplete
Long-term use of Amoxicillin is associated with lower levels of the following nutrients based on peer-reviewed clinical research. WePattern surfaces these patterns from its clinical Knowledge Graph.
- Vitamin B1 (Thiamine)
- Vitamin B2 (Riboflavin)
- Vitamin B3 (Niacin)
- Vitamin B6
- Vitamin B12
- Vitamin K2
- Biotin
- Probiotics / Beneficial bacteria
- Magnesium
- Zinc
- Iron
Common Side Effects of Amoxicillin
- Diarrhea (very common — gut flora disruption)
- Nausea and vomiting
- Stomach cramps and bloating
- Skin rash (can be severe if mononucleosis is undiagnosed — amoxicillin rash)
- Allergic reaction (mild rash to severe anaphylaxis)
- Yeast overgrowth / vaginal candidiasis
- Oral thrush (Candida)
- C. difficile infection (rare but serious — persistent diarrhea post-antibiotic)
Key Drug Interactions — Amoxicillin
Amoxicillin has 6 documented drug-drug interactions in WePattern's Pattern Health Intelligence database. Key interactions include:
- Warfarin (amoxicillin disrupts vitamin K-producing gut bacteria — raises INR/bleeding risk)
- Methotrexate (amoxicillin reduces methotrexate clearance — toxicity risk)
- Oral contraceptives (theoretical reduction in effectiveness — gut flora disruption)
- Allopurinol (increases amoxicillin rash risk significantly)
- Other antibiotics (combination may alter coverage or resistance patterns)
- Probenecid (increases amoxicillin blood levels)
Frequently Asked Questions
Does Amoxicillin deplete nutrients?
Yes. Amoxicillin has been associated with depletion of Vitamin B1 (Thiamine), Vitamin B2 (Riboflavin), Vitamin B3 (Niacin), Vitamin B6, Vitamin B12, Vitamin K2, Biotin, Probiotics / Beneficial bacteria, Magnesium, Zinc, Iron based on clinical research. WePattern maps these relationships from peer-reviewed sources.
What nutrients does Amoxicillin deplete?
Amoxicillin is associated with lower levels of: Vitamin B1 (Thiamine), Vitamin B2 (Riboflavin), Vitamin B3 (Niacin), Vitamin B6, Vitamin B12, Vitamin K2, Biotin, Probiotics / Beneficial bacteria, Magnesium, Zinc, Iron. These depletions can develop over weeks to months of regular use.
What are the side effects of Amoxicillin?
Common side effects associated with Amoxicillin include: Diarrhea (very common — gut flora disruption); Nausea and vomiting; Stomach cramps and bloating; Skin rash (can be severe if mononucleosis is undiagnosed — amoxicillin rash); Allergic reaction (mild rash to severe anaphylaxis).