Colchicine — Nutrient Associations & Health Patterns
Also known as: Colchicine (Colcrys, Mitigare, Lodoco)
Drug Class: Anti-inflammatory — microtubule inhibitor
Ancient anti-inflammatory drug derived from the autumn crocus plant used for acute gout flares, gout prevention, familial Mediterranean fever (FMF), and cardiovascular inflammation (pericarditis, ASCVD prevention in LoDoCo trials). Works by disrupting microtubule polymerization in neutrophils, preventing their migration to joints during gout attacks. Has an extremely narrow therapeutic index — the line between effective and toxic doses is dangerously close. More recently used at ultra-low doses (0.5mg/day) for cardiovascular inflammation. Only evidence-qualified catalog relationships are listed here. Other catalog entries remain unverified in this reference; absence from the list does not rule out other medication effects or interactions.
Medication and Nutrition Context
Only evidence-qualified catalog relationships are listed here. Other catalog entries remain unverified in this reference; absence from the list does not rule out other medication effects or interactions.
Common Side Effects of Colchicine
- Diarrhea (most common — dose-limiting side effect)
- Nausea and vomiting
- Abdominal cramping
- Muscle weakness or pain (myopathy — especially with statin co-use)
- Bone marrow suppression (at toxic or chronic high doses)
- Hair loss (with prolonged use)
- Peripheral neuropathy (rare, chronic use)
- Colchicine toxicity: severe diarrhea, multiorgan failure (no antidote)
Key Drug Interactions — Colchicine
Colchicine has 9 documented drug-drug interactions in WePattern's Pattern Health Intelligence database. Key interactions include:
- Statins (increased myopathy and rhabdomyolysis risk — especially simvastatin)
- Cyclosporine (10-fold increase in colchicine levels — toxicity)
- Clarithromycin, erythromycin (raise colchicine to toxic levels — CYP3A4 inhibition)
- Fluconazole, itraconazole (raise colchicine levels)
- Verapamil, diltiazem (raise colchicine levels — P-gp inhibition)
- Amiodarone (raises colchicine levels)
Frequently Asked Questions
What nutrient associations are reported for Colchicine?
Only evidence-qualified catalog relationships are listed here. Other catalog entries remain unverified in this reference; absence from the list does not rule out other medication effects or interactions.
Which nutrient relationships are mapped for Colchicine?
Only evidence-qualified catalog relationships are listed here. Other catalog entries remain unverified in this reference; absence from the list does not rule out other medication effects or interactions.
What are the side effects of Colchicine?
Common side effects associated with Colchicine include: Diarrhea (most common — dose-limiting side effect); Nausea and vomiting; Abdominal cramping; Muscle weakness or pain (myopathy — especially with statin co-use); Bone marrow suppression (at toxic or chronic high doses).