Colchicine — Nutrient Associations & Health Patterns
Also known as: Colchicine (Colcrys, Mitigare, Lodoco)
Drug Class: Anti-inflammatory — microtubule inhibitor
Colchicine is a Anti-inflammatory — microtubule inhibitor that may affect nutrient status or medication timing in some contexts. WePattern Pattern Health Intelligence maps evidence-qualified nutrient associations, side effects, and interaction context linked to Colchicine.
Reported Nutrient Associations for Colchicine
Peer-reviewed research reports relationships involving the following nutrients. WePattern surfaces them as evidence-qualified associations; they do not establish deficiency, causation, or a fixed timeline for an individual.
- Vitamin B12
- Folic acid
- Magnesium
- Potassium
- Beta-carotene
Common Side Effects of Colchicine
- Diarrhea (most common — dose-limiting side effect)
- Nausea and vomiting
- Abdominal cramping
- Muscle weakness or pain (myopathy — especially with statin co-use)
- Bone marrow suppression (at toxic or chronic high doses)
- Hair loss (with prolonged use)
- Peripheral neuropathy (rare, chronic use)
- Colchicine toxicity: severe diarrhea, multiorgan failure (no antidote)
Key Drug Interactions — Colchicine
Colchicine has 9 documented drug-drug interactions in WePattern's Pattern Health Intelligence database. Key interactions include:
- Statins (increased myopathy and rhabdomyolysis risk — especially simvastatin)
- Cyclosporine (10-fold increase in colchicine levels — toxicity)
- Clarithromycin, erythromycin (raise colchicine to toxic levels — CYP3A4 inhibition)
- Fluconazole, itraconazole (raise colchicine levels)
- Verapamil, diltiazem (raise colchicine levels — P-gp inhibition)
- Amiodarone (raises colchicine levels)
Frequently Asked Questions
What nutrient associations are reported for Colchicine?
Colchicine has reported nutrient associations involving Vitamin B12, Folic acid, Magnesium, Potassium, Beta-carotene in clinical research. This does not establish that every person will become deficient or that the medication caused an individual result.
Which nutrient relationships are mapped for Colchicine?
WePattern maps reported associations involving: Vitamin B12, Folic acid, Magnesium, Potassium, Beta-carotene. The strength, mechanism, dose, duration, and clinical relevance vary, so a clinician or pharmacist should interpret them in context.
What are the side effects of Colchicine?
Common side effects associated with Colchicine include: Diarrhea (most common — dose-limiting side effect); Nausea and vomiting; Abdominal cramping; Muscle weakness or pain (myopathy — especially with statin co-use); Bone marrow suppression (at toxic or chronic high doses).