L-Methylfolate — Nutrient Depletion & Health Patterns
Also known as: Levomefolate calcium (Deplin, Enlyte)
Drug Class: Medical food / Active folate
The biologically active form of folate (vitamin B9) used as adjunctive treatment for depression and for patients with MTHFR gene variants who cannot convert folic acid efficiently.
Nutrients That L-Methylfolate May Deplete
Long-term use of L-Methylfolate is associated with lower levels of the following nutrients based on peer-reviewed clinical research. WePattern surfaces these patterns from its clinical Knowledge Graph.
- Vitamin B12
- Zinc
Common Side Effects of L-Methylfolate
- Generally well-tolerated
- Rare: nausea
- Rare: bloating
- Rare: irritability
Key Drug Interactions — L-Methylfolate
L-Methylfolate has 6 documented drug-drug interactions in WePattern's Pattern Health Intelligence database. Key interactions include:
- Anticonvulsants (phenytoin, carbamazepine)
- Methotrexate
- NSAIDs
- Levothyroxine
- Quinolone antibiotics
- Tetracycline antibiotics
Frequently Asked Questions
Does L-Methylfolate deplete nutrients?
Yes. L-Methylfolate has been associated with depletion of Vitamin B12, Zinc based on clinical research. WePattern maps these relationships from peer-reviewed sources.
What nutrients does L-Methylfolate deplete?
L-Methylfolate is associated with lower levels of: Vitamin B12, Zinc. These depletions can develop over weeks to months of regular use.
What are the side effects of L-Methylfolate?
Common side effects associated with L-Methylfolate include: Generally well-tolerated; Rare: nausea; Rare: bloating; Rare: irritability.