Naltrexone — Nutrient Associations & Health Patterns
Also known as: Naltrexone / Low Dose Naltrexone — LDN (ReVia, Vivitrol, Contrave)
Drug Class: Opioid antagonist / Immunomodulator (LDN)
Naltrexone is a Opioid antagonist / Immunomodulator (LDN) that may affect nutrient status or medication timing in some contexts. WePattern Pattern Health Intelligence maps evidence-qualified nutrient associations, side effects, and interaction context linked to Naltrexone.
Reported Nutrient Associations for Naltrexone
Peer-reviewed research reports relationships involving the following nutrients. WePattern surfaces them as evidence-qualified associations; they do not establish deficiency, causation, or a fixed timeline for an individual.
- Endorphins (endogenous opioid peptides — rebound effect is therapeutic at LDN doses)
- Vitamin D
- Magnesium
Common Side Effects of Naltrexone
- Standard dose (50mg): Nausea (most common early), headache, fatigue, sleep disturbances, loss of appetite
- LDN (1.5–4.5mg): Vivid dreams or sleep disturbances (most common early side effect), transient nausea
- Liver toxicity risk (standard doses — baseline liver function required)
- Precipitation of opioid withdrawal (if opioids present in system at initiation)
- Depression (rare — opioid system modulation)
Key Drug Interactions — Naltrexone
Naltrexone has 5 documented drug-drug interactions in WePattern's Pattern Health Intelligence database. Key interactions include:
- Opioids — ABSOLUTE CONTRAINDICATION (naltrexone precipitates immediate withdrawal — 7–10 day opioid-free period required before starting)
- Opioid-containing medications (cold medications, cough syrups, Imodium — will not work while on naltrexone)
- Thioridazine (antipsychotic — lethargy and drowsiness)
- Disulfiram (combined use for alcohol disorder — increased hepatotoxicity risk)
- Immunosuppressants (at LDN doses — theoretical interaction — monitor with rheumatologist)
Frequently Asked Questions
What nutrient associations are reported for Naltrexone?
Naltrexone has reported nutrient associations involving Endorphins (endogenous opioid peptides — rebound effect is therapeutic at LDN doses), Vitamin D, Magnesium in clinical research. This does not establish that every person will become deficient or that the medication caused an individual result.
Which nutrient relationships are mapped for Naltrexone?
WePattern maps reported associations involving: Endorphins (endogenous opioid peptides — rebound effect is therapeutic at LDN doses), Vitamin D, Magnesium. The strength, mechanism, dose, duration, and clinical relevance vary, so a clinician or pharmacist should interpret them in context.
What are the side effects of Naltrexone?
Common side effects associated with Naltrexone include: Standard dose (50mg): Nausea (most common early), headache, fatigue, sleep disturbances, loss of appetite; LDN (1.5–4.5mg): Vivid dreams or sleep disturbances (most common early side effect), transient nausea; Liver toxicity risk (standard doses — baseline liver function required); Precipitation of opioid withdrawal (if opioids present in system at initiation); Depression (rare — opioid system modulation).
Explore Related Health Intelligence
- All Medications & Nutrient Association Database
- Medication–Nutrient Relationships — Clinical Guide
- Vitamin D — Deficiency Patterns & Health Impact
- PPIs and Magnesium: The Hidden Cost of Acid Blockers
- RxNext™ — Enter Your Medication List for Full Pattern Analysis
- WePattern Health Assessment — Find Your Full Pattern