Pregabalin — Nutrient Depletion & Health Patterns
Also known as: Pregabalin (Lyrica, Lyrica CR)
Drug Class: Gabapentinoid / Anticonvulsant
Calcium channel alpha-2-delta ligand used for neuropathic pain, fibromyalgia, generalized anxiety disorder, and partial-onset seizures. More potent and predictably absorbed than gabapentin. Widely prescribed for diabetic neuropathy, post-herpetic neuralgia, and central sensitization conditions. Schedule V controlled substance.
Nutrients That Pregabalin May Deplete
Long-term use of Pregabalin is associated with lower levels of the following nutrients based on peer-reviewed clinical research. WePattern surfaces these patterns from its clinical Knowledge Graph.
- Vitamin B1 (Thiamine)
- Vitamin B6
- Folic acid
- CoQ10
- Carnitine
Common Side Effects of Pregabalin
- Dizziness and drowsiness
- Weight gain
- Peripheral edema (fluid retention in legs/feet)
- Blurred vision
- Dry mouth
- Cognitive impairment / brain fog
- Mood changes (depression risk)
- Discontinuation syndrome (anxiety, insomnia, sweating — taper required)
Key Drug Interactions — Pregabalin
Pregabalin has 7 documented drug-drug interactions in WePattern's Pattern Health Intelligence database. Key interactions include:
- Opioids (additive CNS/respiratory depression — high risk)
- Benzodiazepines (additive sedation and respiratory depression)
- Alcohol (severe CNS depression)
- CNS depressants
- ACE inhibitors (edema risk)
- Thiazolidinediones (edema risk — pioglitazone, rosiglitazone)
Frequently Asked Questions
Does Pregabalin deplete nutrients?
Yes. Pregabalin has been associated with depletion of Vitamin B1 (Thiamine), Vitamin B6, Folic acid, CoQ10, Carnitine based on clinical research. WePattern maps these relationships from peer-reviewed sources.
What nutrients does Pregabalin deplete?
Pregabalin is associated with lower levels of: Vitamin B1 (Thiamine), Vitamin B6, Folic acid, CoQ10, Carnitine. These depletions can develop over weeks to months of regular use.
What are the side effects of Pregabalin?
Common side effects associated with Pregabalin include: Dizziness and drowsiness; Weight gain; Peripheral edema (fluid retention in legs/feet); Blurred vision; Dry mouth.