Pregabalin — Nutrient Associations & Health Patterns
Also known as: Pregabalin (Lyrica, Lyrica CR)
Drug Class: Gabapentinoid / Anticonvulsant
Calcium channel alpha-2-delta ligand used for neuropathic pain, fibromyalgia, generalized anxiety disorder, and partial-onset seizures. More potent and predictably absorbed than gabapentin. Widely prescribed for diabetic neuropathy, post-herpetic neuralgia, and central sensitization conditions. Schedule V controlled substance. Only evidence-qualified catalog relationships are listed here. Other catalog entries remain unverified in this reference; absence from the list does not rule out other medication effects or interactions.
Medication and Nutrition Context
Only evidence-qualified catalog relationships are listed here. Other catalog entries remain unverified in this reference; absence from the list does not rule out other medication effects or interactions.
Common Side Effects of Pregabalin
- Dizziness and drowsiness
- Weight gain
- Peripheral edema (fluid retention in legs/feet)
- Blurred vision
- Dry mouth
- Cognitive impairment / brain fog
- Mood changes (depression risk)
- Discontinuation syndrome (anxiety, insomnia, sweating — taper required)
Key Drug Interactions — Pregabalin
Pregabalin has 7 documented drug-drug interactions in WePattern's Pattern Health Intelligence database. Key interactions include:
- Opioids (additive CNS/respiratory depression — high risk)
- Benzodiazepines (additive sedation and respiratory depression)
- Alcohol (severe CNS depression)
- CNS depressants
- ACE inhibitors (edema risk)
- Thiazolidinediones (edema risk — pioglitazone, rosiglitazone)
Frequently Asked Questions
What nutrient associations are reported for Pregabalin?
Only evidence-qualified catalog relationships are listed here. Other catalog entries remain unverified in this reference; absence from the list does not rule out other medication effects or interactions.
Which nutrient relationships are mapped for Pregabalin?
Only evidence-qualified catalog relationships are listed here. Other catalog entries remain unverified in this reference; absence from the list does not rule out other medication effects or interactions.
What are the side effects of Pregabalin?
Common side effects associated with Pregabalin include: Dizziness and drowsiness; Weight gain; Peripheral edema (fluid retention in legs/feet); Blurred vision; Dry mouth.