Pregabalin — Nutrient Associations & Health Patterns
Also known as: Pregabalin (Lyrica, Lyrica CR)
Drug Class: Gabapentinoid / Anticonvulsant
Pregabalin is a Gabapentinoid / Anticonvulsant that may affect nutrient status or medication timing in some contexts. WePattern Pattern Health Intelligence maps evidence-qualified nutrient associations, side effects, and interaction context linked to Pregabalin.
Reported Nutrient Associations for Pregabalin
Peer-reviewed research reports relationships involving the following nutrients. WePattern surfaces them as evidence-qualified associations; they do not establish deficiency, causation, or a fixed timeline for an individual.
- Vitamin B1 (Thiamine)
- Vitamin B6
- Folic acid
- CoQ10
- Carnitine
Common Side Effects of Pregabalin
- Dizziness and drowsiness
- Weight gain
- Peripheral edema (fluid retention in legs/feet)
- Blurred vision
- Dry mouth
- Cognitive impairment / brain fog
- Mood changes (depression risk)
- Discontinuation syndrome (anxiety, insomnia, sweating — taper required)
Key Drug Interactions — Pregabalin
Pregabalin has 7 documented drug-drug interactions in WePattern's Pattern Health Intelligence database. Key interactions include:
- Opioids (additive CNS/respiratory depression — high risk)
- Benzodiazepines (additive sedation and respiratory depression)
- Alcohol (severe CNS depression)
- CNS depressants
- ACE inhibitors (edema risk)
- Thiazolidinediones (edema risk — pioglitazone, rosiglitazone)
Frequently Asked Questions
What nutrient associations are reported for Pregabalin?
Pregabalin has reported nutrient associations involving Vitamin B1 (Thiamine), Vitamin B6, Folic acid, CoQ10, Carnitine in clinical research. This does not establish that every person will become deficient or that the medication caused an individual result.
Which nutrient relationships are mapped for Pregabalin?
WePattern maps reported associations involving: Vitamin B1 (Thiamine), Vitamin B6, Folic acid, CoQ10, Carnitine. The strength, mechanism, dose, duration, and clinical relevance vary, so a clinician or pharmacist should interpret them in context.
What are the side effects of Pregabalin?
Common side effects associated with Pregabalin include: Dizziness and drowsiness; Weight gain; Peripheral edema (fluid retention in legs/feet); Blurred vision; Dry mouth.