Quetiapine — Nutrient Depletion & Health Patterns

Also known as: Quetiapine (Seroquel, Seroquel XR)

Drug Class: Atypical antipsychotic

Second-generation atypical antipsychotic used for schizophrenia, bipolar I and II disorder, and major depressive disorder (as augmentation). Widely prescribed off-label at low doses (12.5–100mg) for insomnia due to its strong antihistamine (H1) activity — despite carrying full antipsychotic risk at any dose. One of the most prescribed psychiatric medications globally. Metabolic monitoring (weight, glucose, cholesterol) is mandatory due to significant metabolic side effect profile.

Nutrients That Quetiapine May Deplete

Long-term use of Quetiapine is associated with lower levels of the following nutrients based on peer-reviewed clinical research. WePattern surfaces these patterns from its clinical Knowledge Graph.

CoQ10
Vitamin D
Magnesium
Melatonin
Vitamin B12

Common Side Effects of Quetiapine

Sedation and drowsiness (dose-dependent — exploited at low doses for insomnia)
Weight gain (significant — often 10–30 lbs over months — metabolic monitoring mandatory)
Elevated blood glucose and type 2 diabetes risk
Elevated cholesterol and triglycerides
Orthostatic hypotension (dizziness on standing — fall risk)
Dry mouth
Constipation
QT prolongation (cardiac arrhythmia risk at higher doses)

Key Drug Interactions — Quetiapine

Quetiapine has 9 documented drug-drug interactions in WePattern's Pattern Health Intelligence database. Key interactions include:

CNS depressants — benzodiazepines, opioids, alcohol (additive sedation and respiratory depression)
QT-prolonging drugs — antiarrhythmics, azithromycin, fluoroquinolones (cardiac arrhythmia risk)
CYP3A4 inhibitors — ketoconazole, clarithromycin (raise quetiapine levels significantly)
CYP3A4 inducers — carbamazepine, rifampin, St. John's Wort (reduce quetiapine levels)
Blood pressure medications (additive hypotension — fall risk)
Dopamine agonists — Parkinson's medications (quetiapine opposes dopamine — avoid or use very carefully)

Frequently Asked Questions

Does Quetiapine deplete nutrients?

Yes. Quetiapine has been associated with depletion of CoQ10, Vitamin D, Magnesium, Melatonin, Vitamin B12 based on clinical research. WePattern maps these relationships from peer-reviewed sources.

What nutrients does Quetiapine deplete?

Quetiapine is associated with lower levels of: CoQ10, Vitamin D, Magnesium, Melatonin, Vitamin B12. These depletions can develop over weeks to months of regular use.

What are the side effects of Quetiapine?

Common side effects associated with Quetiapine include: Sedation and drowsiness (dose-dependent — exploited at low doses for insomnia); Weight gain (significant — often 10–30 lbs over months — metabolic monitoring mandatory); Elevated blood glucose and type 2 diabetes risk; Elevated cholesterol and triglycerides; Orthostatic hypotension (dizziness on standing — fall risk).