Quetiapine — Nutrient Associations & Health Patterns
Also known as: Quetiapine (Seroquel, Seroquel XR)
Drug Class: Atypical antipsychotic
Second-generation atypical antipsychotic used for schizophrenia, bipolar I and II disorder, and major depressive disorder (as augmentation). Widely prescribed off-label at low doses (12.5–100mg) for insomnia due to its strong antihistamine (H1) activity — despite carrying full antipsychotic risk at any dose. One of the most prescribed psychiatric medications globally. Metabolic monitoring (weight, glucose, cholesterol) is mandatory due to significant metabolic side effect profile. Only evidence-qualified catalog relationships are listed here. Other catalog entries remain unverified in this reference; absence from the list does not rule out other medication effects or interactions.
Medication and Nutrition Context
Only evidence-qualified catalog relationships are listed here. Other catalog entries remain unverified in this reference; absence from the list does not rule out other medication effects or interactions.
Common Side Effects of Quetiapine
- Sedation and drowsiness (dose-dependent — exploited at low doses for insomnia)
- Weight gain (significant — often 10–30 lbs over months — metabolic monitoring mandatory)
- Elevated blood glucose and type 2 diabetes risk
- Elevated cholesterol and triglycerides
- Orthostatic hypotension (dizziness on standing — fall risk)
- Dry mouth
- Constipation
- QT prolongation (cardiac arrhythmia risk at higher doses)
Key Drug Interactions — Quetiapine
Quetiapine has 9 documented drug-drug interactions in WePattern's Pattern Health Intelligence database. Key interactions include:
- CNS depressants — benzodiazepines, opioids, alcohol (additive sedation and respiratory depression)
- QT-prolonging drugs — antiarrhythmics, azithromycin, fluoroquinolones (cardiac arrhythmia risk)
- CYP3A4 inhibitors — ketoconazole, clarithromycin (raise quetiapine levels significantly)
- CYP3A4 inducers — carbamazepine, rifampin, St. John's Wort (reduce quetiapine levels)
- Blood pressure medications (additive hypotension — fall risk)
- Dopamine agonists — Parkinson's medications (quetiapine opposes dopamine — avoid or use very carefully)
Frequently Asked Questions
What nutrient associations are reported for Quetiapine?
Only evidence-qualified catalog relationships are listed here. Other catalog entries remain unverified in this reference; absence from the list does not rule out other medication effects or interactions.
Which nutrient relationships are mapped for Quetiapine?
Only evidence-qualified catalog relationships are listed here. Other catalog entries remain unverified in this reference; absence from the list does not rule out other medication effects or interactions.
What are the side effects of Quetiapine?
Common side effects associated with Quetiapine include: Sedation and drowsiness (dose-dependent — exploited at low doses for insomnia); Weight gain (significant — often 10–30 lbs over months — metabolic monitoring mandatory); Elevated blood glucose and type 2 diabetes risk; Elevated cholesterol and triglycerides; Orthostatic hypotension (dizziness on standing — fall risk).