Spironolactone — Nutrient Depletion & Health Patterns
Also known as: Spironolactone (Aldactone, CaroSpir)
Drug Class: Potassium-sparing diuretic / Androgen blocker
Potassium-sparing diuretic and aldosterone antagonist used for heart failure, fluid retention, high blood pressure, and hormonal conditions including PCOS, hormonal acne, and female pattern hair loss. Blocks androgen receptors — popular off-label for skin and hair in women.
Nutrients That Spironolactone May Deplete
Long-term use of Spironolactone is associated with lower levels of the following nutrients based on peer-reviewed clinical research. WePattern surfaces these patterns from its clinical Knowledge Graph.
- Zinc
- Folic acid
- Sodium
- Calcium
Common Side Effects of Spironolactone
- Elevated potassium (hyperkalemia)
- Breast tenderness
- Irregular periods
- Dizziness
- Low sodium (hyponatremia)
- Increased urination
- Fatigue
- Breast growth in men (gynecomastia)
Key Drug Interactions — Spironolactone
Spironolactone has 9 documented drug-drug interactions in WePattern's Pattern Health Intelligence database. Key interactions include:
- Potassium supplements (DANGEROUS — can cause fatal hyperkalemia)
- ACE inhibitors
- ARBs
- NSAIDs
- Digoxin
- Lithium
Frequently Asked Questions
Does Spironolactone deplete nutrients?
Yes. Spironolactone has been associated with depletion of Zinc, Folic acid, Sodium, Calcium based on clinical research. WePattern maps these relationships from peer-reviewed sources.
What nutrients does Spironolactone deplete?
Spironolactone is associated with lower levels of: Zinc, Folic acid, Sodium, Calcium. These depletions can develop over weeks to months of regular use.
What are the side effects of Spironolactone?
Common side effects associated with Spironolactone include: Elevated potassium (hyperkalemia); Breast tenderness; Irregular periods; Dizziness; Low sodium (hyponatremia).