Trazodone — Nutrient Depletion & Health Patterns
Also known as: Trazodone hydrochloride (Desyrel, Oleptro)
Drug Class: SARI Antidepressant / Sleep aid
Serotonin antagonist and reuptake inhibitor (SARI) used for depression and insomnia. At low doses (25–100mg), widely used as a sleep aid. At therapeutic antidepressant doses (150–400mg), treats major depression. Favored over benzodiazepines for insomnia because it is non-habit-forming.
Nutrients That Trazodone May Deplete
Long-term use of Trazodone is associated with lower levels of the following nutrients based on peer-reviewed clinical research. WePattern surfaces these patterns from its clinical Knowledge Graph.
- CoQ10
- Vitamin B12
- Melatonin
- Magnesium
- Vitamin B6
Common Side Effects of Trazodone
- Drowsiness (used therapeutically for sleep)
- Dizziness
- Dry mouth
- Blurred vision
- Low blood pressure
- Headache
- Nausea
- Priapism (rare but serious in men)
Key Drug Interactions — Trazodone
Trazodone has 8 documented drug-drug interactions in WePattern's Pattern Health Intelligence database. Key interactions include:
- MAOIs (deadly — 14-day washout)
- Other serotonin-affecting drugs (serotonin syndrome)
- Blood pressure medications (additive lowering effect)
- Digoxin
- Warfarin
- CNS depressants and alcohol (additive sedation)
Frequently Asked Questions
Does Trazodone deplete nutrients?
Yes. Trazodone has been associated with depletion of CoQ10, Vitamin B12, Melatonin, Magnesium, Vitamin B6 based on clinical research. WePattern maps these relationships from peer-reviewed sources.
What nutrients does Trazodone deplete?
Trazodone is associated with lower levels of: CoQ10, Vitamin B12, Melatonin, Magnesium, Vitamin B6. These depletions can develop over weeks to months of regular use.
What are the side effects of Trazodone?
Common side effects associated with Trazodone include: Drowsiness (used therapeutically for sleep); Dizziness; Dry mouth; Blurred vision; Low blood pressure.