Venlafaxine — Nutrient Depletion & Health Patterns
Also known as: Venlafaxine hydrochloride (Effexor, Effexor XR)
Drug Class: SNRI Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI) used for major depression, generalized anxiety disorder, panic disorder, and social anxiety. One of the most widely prescribed antidepressants. Also used off-label for chronic pain, fibromyalgia, hot flashes, and ADHD.
Nutrients That Venlafaxine May Deplete
Long-term use of Venlafaxine is associated with lower levels of the following nutrients based on peer-reviewed clinical research. WePattern surfaces these patterns from its clinical Knowledge Graph.
- Vitamin B12
- Folic acid
- Vitamin B6
- CoQ10
- Melatonin
- Magnesium
Common Side Effects of Venlafaxine
- Nausea (common early)
- Insomnia
- Headache
- Dizziness
- Dry mouth
- Sweating
- Sexual dysfunction
- High blood pressure (especially at higher doses)
Key Drug Interactions — Venlafaxine
Venlafaxine has 9 documented drug-drug interactions in WePattern's Pattern Health Intelligence database. Key interactions include:
- MAOIs (deadly combination — 14-day washout required)
- Other serotonin-affecting drugs (serotonin syndrome risk)
- Blood thinners (increased bleeding risk)
- NSAIDs (GI bleed risk)
- Tramadol
- Linezolid
Frequently Asked Questions
Does Venlafaxine deplete nutrients?
Yes. Venlafaxine has been associated with depletion of Vitamin B12, Folic acid, Vitamin B6, CoQ10, Melatonin, Magnesium based on clinical research. WePattern maps these relationships from peer-reviewed sources.
What nutrients does Venlafaxine deplete?
Venlafaxine is associated with lower levels of: Vitamin B12, Folic acid, Vitamin B6, CoQ10, Melatonin, Magnesium. These depletions can develop over weeks to months of regular use.
What are the side effects of Venlafaxine?
Common side effects associated with Venlafaxine include: Nausea (common early); Insomnia; Headache; Dizziness; Dry mouth.