Xarelto — Nutrient Depletion & Health Patterns
Also known as: Rivaroxaban (Xarelto)
Drug Class: Direct oral anticoagulant (DOAC) — Factor Xa inhibitor
Direct Factor Xa inhibitor anticoagulant used to prevent stroke in atrial fibrillation, treat and prevent DVT and pulmonary embolism, and prevent blood clots after knee or hip replacement. One of the most prescribed DOACs alongside Eliquis (apixaban). Unlike warfarin, does not require routine INR monitoring. Has no antidote reversal agent in most settings (andexanet alfa is expensive and rarely available).
Nutrients That Xarelto May Deplete
Long-term use of Xarelto is associated with lower levels of the following nutrients based on peer-reviewed clinical research. WePattern surfaces these patterns from its clinical Knowledge Graph.
- Vitamin K2
- Coenzyme Q10 (CoQ10)
Common Side Effects of Xarelto
- Bleeding (the primary risk — internal, GI, or external)
- Bruising easily
- Prolonged bleeding from cuts
- GI bleeding (stomach pain, bloody or black stools)
- Nausea
- Back pain (can signal spinal bleed if on anticoagulants)
- Fatigue
- Dizziness
Key Drug Interactions — Xarelto
Xarelto has 9 documented drug-drug interactions in WePattern's Pattern Health Intelligence database. Key interactions include:
- NSAIDs (ibuprofen, naproxen — significantly increased bleeding risk)
- Aspirin (additive bleeding risk — high)
- Other anticoagulants or antiplatelets (clopidogrel, warfarin — high bleeding risk)
- CYP3A4 inhibitors (azole antifungals, clarithromycin — raise rivaroxaban levels → bleeding)
- CYP3A4 inducers (rifampin, St. John's Wort — reduce rivaroxaban levels → clotting)
- Strong P-gp inhibitors (certain HIV drugs, amiodarone — raise rivaroxaban levels)
Frequently Asked Questions
Does Xarelto deplete nutrients?
Yes. Xarelto has been associated with depletion of Vitamin K2, Coenzyme Q10 (CoQ10) based on clinical research. WePattern maps these relationships from peer-reviewed sources.
What nutrients does Xarelto deplete?
Xarelto is associated with lower levels of: Vitamin K2, Coenzyme Q10 (CoQ10). These depletions can develop over weeks to months of regular use.
What are the side effects of Xarelto?
Common side effects associated with Xarelto include: Bleeding (the primary risk — internal, GI, or external); Bruising easily; Prolonged bleeding from cuts; GI bleeding (stomach pain, bloody or black stools); Nausea.